Longe da televisão, Kudrow já atuou em vários filmes de Hollywood. Incluindo Romy and Michele's High School Reunion (1997), The Opposite of Sex (1998), Analyze This (1999), Dr. Dolittle 2 (2001), Happy Endings (2005), P.S. I Love You (2007), Bandslam (2008), Hotel for Dogs (2009) e Easy A (2010).