Optic Nerve may refer to:

• Optic nerve, the anatomical structure
• Optic Nerve (GCHQ), a mass surveillance program run by the British intelligence agency GCHQ
• Optic Nerve (comic), the comic book series
• Optic Nerve (CD-ROM), a Red Hot Benefit Series tribute to David Wojnarowicz
• Optic Nerve Studios, a special make-up effects studio run by Glenn Hetrick

The optic nerve, also known as cranial nerve II, is a paired nerve that transmits visual information from the retina to the brain. The optic nerve is derived from optic stalks during the seventh week of development and is composed of retinal ganglion cell axons and glial cells. In humans, the optic nerve extends from the optic disc to the optic chiasm and continues as the optic tract to the lateral geniculate nucleus, pretectal nuclei, and superior colliculus.