The G beta-gamma complex (G_βγ) is a tightly bound dimeric protein complex, composed of one G_β and one G_γ subunit, and is a component of heterotrimeric G proteins. Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, and gamma subunits, or G_α, G_β, and G_γ. When a G protein-coupled receptor (GPCR) is activated, G_α dissociates from G_βγ, allowing both subunits to perform their respective downstream signaling effects. One of the major functions of G_βγ is the inhibition of the G_α subunit.