Substance Abuse may mean:

• substance abuse, such as drug abuse
• Substance Abuse (band), a hip-hop group
• Substance Abuse (album), an unofficial New Order remix album
• Substance Abuse (Eureka Seven episode)

Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder. Widely differing definitions of drug abuse are used in public health, medical and criminal justice contexts.