The Pueblo Revolt of 1680 — also known as Popé's Rebellion — was an uprising of most of the indigenous Pueblo people against the Spanish colonizers in the province of Santa Fe de Nuevo México, present day New Mexico. The Pueblo Revolt killed 400 Spanish and drove the remaining 2,000 settlers out of the province. Twelve years later the Spanish returned and were able to reoccupy New Mexico with little opposition.