Isla Ángel de la Guarda, also called Archangel Island, is a large island in the Gulf of California (Sea of Cortez) east of Bahía de los Ángeles in northwestern Mexico, separated from the Baja California Peninsula by the Canal de Ballenas (Whales Channel). It is the second largest of the eleven Midriff Islands or Islas Grandes. It is part of the state of Baja California, located northwest of Tiburón Island. The island is uninhabited, and is a biological reserve called Isla Angel de la Guarda National Park. The island is part of the Mexicali municipality.