Guizhou (; postal: Kweichow) is a province of the People's Republic of China located in the southwestern part of the country. Its provincial capital city is Guiyang.

Guizhou or Gui Prefecture (媯州) was a zhou (prefecture) in imperial China, centering on modern Zhangjiakou, Hebei, China. It was created in 634 by the Tang dynasty and was later ceded by Later Jin to the Khitan-ruled Liao dynasty as one of the Sixteen Prefectures.