Grande Terre or Grande-Terre (French for "large land") is a generic term used in French to designate the main island of any given archipelago. As a specific toponym, it may refer to the following:

• Grande-Terre, the eastern half of the main island of Guadeloupe (divided by a canal across a narrow isthmus)
• Grande-Terre (Kerguelen), the main island of the Kerguelen Islands of the French Southern and Antarctic Lands
• Grande-Terre (Mayotte), the main island of Mayotte
• Grande Terre (New Caledonia), the main island of New Caledonia

Grande-Terre Island is the name of the eastern-half of Guadeloupe proper, in the Lesser Antilles. It is separated from the other half of Guadeloupe island, Basse-Terre, by a narrow sea channel called Rivière Salée (in English Salt River). Pointe de la Grande Vigie, in Grande-Terre, is the northernmost point of Guadeloupe island. To the east lies La Désirade, to the south lies Marie Galante