Cuyahoga County ( or or ) is a county located in the U.S. state of Ohio. As of the 2010 census, the population was 1,280,122, making it the most populous county in Ohio. Its county seat is Cleveland. In 2014, the county's estimated population was 1,259,828. The county is named after the Iroquoian word Cuyahoga, which means 'crooked river'. The name is also assigned to the Cuyahoga River, which bisects the county.