The province of Medio Campidano (; ) is a province in the autonomous region of Sardinia, Italy. As of 2015, the province has a population of 100,141 inhabitants over an area of , giving it a population density of 66 inhabitants per square kilometre. It has two chief towns, Villacidro and Sanluri, with 14,245 and 8,543 inhabitants, respectfully. It was established in 2005 from a section of the province of Cagliari. It contains 28 comuni (singular: comune) and the president of the province is Fulvio Tocco.