Prajna may refer to:

• Prajña (Hinduism), a Hindu concept
• Prajña (Buddhism), a Buddhist concept
• Prajna (Buddhist monk), an important 9th century Buddhist monk from Gandhara

Pañña (Pali) or prajña (Sanskrit) "wisdom", is insight in the true nature of reality, namely primarily anicca (impermanence), dukkha (dissatisfaction or suffering), anatta (non-self) and sunyata (emptiness).