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Myeloperoxidase
Myeloperoxidase
(MPO) is a
peroxidase
enzyme
that in humans is encoded by the
MPO
gene
on
chromosome
17. MPO is most abundantly expressed in
neutrophil granulocytes
(a subtype of
white blood cells
), and produces hypohalous acids to carry out their
antimicrobial
activity. It is a
lysosomal
protein stored in
azurophilic granules
of the neutrophil and released into the
extracellular space
during degranulation. MPO has a
heme
pigment, which causes its green color in secretions rich in neutrophils, such as
pus
and some forms of
mucus
.
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