Multiple organ dysfunction syndrome (
MODS), previously known as
multiple organ failure (
MOF),
total organ failure (
TOF) or
multisystem organ failure (
MSOF), is altered
organ function in an acutely ill patient requiring
medical intervention to achieve
homeostasis. The use of "multiple organ failure" or "multisystem organ failure" should be avoided since that phrase was based upon physiological parameters to determine whether or not a particular organ was failing.