The term
'molten globule' (
MG) was first coined by A. Wada and M . Ohgushi in 1983. It was first found in , which conserves a native-like secondary structure content but without the tightly packed protein interior, under low pH and high salt concentration. For cytochrome c and some other proteins, it has been shown that the molten globule state is a "thermodynamic state" clearly different both from the
native and the
denatured state, demonstrating for the first time the existence of a third equilibirum (i.e., intermediate) state.