In human anatomy, the infraorbital foramen (IOF) is an opening in the maxillary bone of the skull located below the infraorbital margin (IOM) of the orbit (eye socket). It allows passage for the infraorbital artery, vein, and nerve which are branches of the maxillary branch (V2) of the trigeminal nerve (CN V). The IOF-IOM distance varies between . Forming the exterior end of the infraorbital canal, the infraorbital foramen communicates with the infraorbital groove, the canal's opening on the interior side.