The
hydrophobic effect is the observed tendency of
nonpolar substances to aggregate in
aqueous solution and exclude water molecules. This occurs because interactions between the hydrophobic molecules enable the displaced water molecules to make hydrogen bonds more freely with each other and increase the number of hydrogen bonds they are involved with, thereby decreasing the overall free energy. The word hydrophobic literally means "water-fearing," and it describes the
segregation and apparent repulsion between water and nonpolar substances.