Half-Breed may refer to:

• Half-Breed (album), a 1973 album by singer/actress Cher
  • "Half-Breed" (song), the title track from the album
• "Half-Breed" (short story), a science fiction story by Isaac Asimov
• Halfbreed (album), a 1968 album by the Keef Hartley Band
• Half Breed (film), a 1913 Swedish film
• The Half-Breed, a 1952 American film starring Robert Young
• Half-Breed (politics), member of the moderate wing of the United States Republican Party in the late 19th century
• Halfbreed Billy Gram, American professional wrestler and entertainer

Half-breed is a term, now considered derogatory, used to describe anyone who is of mixed race, though it usually refers to people that are half Native American and half European or white. Half-breed is the English version of the French word "métis".