Focal segmental glomerulosclerosis (
FSGS) is a cause of
nephrotic syndrome in children and adolescents, as well as an leading cause of
kidney failure in adults. It is also known as "focal glomerular sclerosis" or "focal nodular glomerulosclerosis." It accounts for about a sixth of the cases of
nephrotic syndrome. (
Minimal change disease (MCD) is by far the most common cause of nephrotic syndrome in children: MCD and primary FSGS may have a similar cause.)