Chills is a feeling of coldness occurring during a high
fever, but sometimes is also a common symptom which occurs alone in specific people. It occurs during fever due to the release of
cytokines and
prostaglandins as part of the inflammatory response, which increases the set point for body temperature in the
hypothalamus. The increased set point causes the body temperature to rise (
pyrexia), but also makes the patient feel cold or chills until the new set point is reached. Shivering also occurs along with chills because the patient's body produces heat during muscle contraction in a physiological attempt to increase body temperature to the new set point. When it does not accompany a high fever it is normally a light chill. Sometimes a chill of medium power and short duration may occur during a scare, especially in scares of fear, commonly interpreted like or confused by trembling.