Anandamide, also known as
N-arachidonoylethanolamine or
AEA, is an
essential fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid) an essential ω-6 polyunsaturated fatty acid. The name is taken from the
Sanskrit word
ananda, which means "joy,
bliss,
delight", and
amide. It is synthesized from N-arachidonoyl phosphatidylethanolamine by multiple pathways. It is degraded primarily by the
fatty acid amide hydrolase (FAAH) enzyme, which converts anandamide into
ethanolamine and
arachidonic acid. As such, inhibitors of FAAH lead to elevated anandamide levels and are being pursued for therapeutic use.