U.S. Route 61 (US 61) is the official designation for a United States highway that runs from New Orleans, Louisiana, to the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River, and is designated the Great River Road for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota is at an intersection with Interstate 35 (I-35). Prior to 1991, the highway extended north on what is now Minnesota State Highway 61 (MN 61) through Duluth to the United States–Canada border near Grand Portage. Its southern terminus in New Orleans is at an intersection with Tulane Avenue at South Broad Street. The highway is often called "The Blues Highway", because of the course it takes from St. Paul to St. Louis, through Memphis, into the Mississippi Delta, and eventually ending in New Orleans.