U.S. Route 322 (US 322) is a U.S. highway running from Cleveland, Ohio east to Atlantic City, New Jersey. In the U.S. state of Pennsylvania, the route runs from the Ohio border in West Shenango Township southeast to the Commodore Barry Bridge over the Delaware River in Chester, at which point the route crosses into New Jersey. The route passes near several cities, including DuBois, State College, and Harrisburg.