U.S. Route 301 (US 301) is a US Highway that passes through the state of Delaware, running from the Maryland border southwest of Middletown north to its northern terminus at US 40 in Glasgow, where the highway continues north toward Newark as Delaware Route 896 (DE 896). US 301 runs through the western part of New Castle County in the northern part of the state, passing through Middletown and crossing the Chesapeake and Delaware Canal on the Summit Bridge. Through the state, US 301 varies between 2 and 4 lanes in width, with some portions a divided highway. US 301 is concurrent with multiple state routes, including DE 15 and DE 299 southwest of Middletown, DE 71 from Middletown to Summit Bridge, and DE 896 from Mount Pleasant to the northern terminus in Glasgow.