U.S. Route 250 (US 250) is a route of the United States Numbered Highway System, and is a spur of U.S. Route 50. It currently runs for from Sandusky, Ohio to Richmond, Virginia. It passes through the states of Virginia, West Virginia, and Ohio. It goes through the cities of Richmond, Virginia, Charlottesville, Virginia, Staunton, Virginia, and Wheeling, West Virginia. West of Pruntytown, West Virginia, US 250 intersects and forms a short overlap with its parent US 50. In West Virginia, the route is signed north–south. In Ohio and Virginia, the route is signed east–west.