Syamzhensky District is an administrative and municipal district (raion), one of the twenty-six in Vologda Oblast, Russia. It is located in the center of the oblast and borders with Vozhegodsky District in the north, Verkhovazhsky District in the northeast, Totemsky District in the east, Sokolsky District in the south, and with Kharovsky District in the west. The area of the district is . Its administrative center is the rural locality (a selo) of Syamzha. District's population: 10,384 (2002 Census); The population of Syamzha accounts for 45.2% of the district's total population.