The Sestra River is a river in Moscow Oblast, Russia. It is a left tributary of the Dubna River (Volga basin). Its source is the Senezh Lake. The length of the river is . The area of its basin is . The river freezes in November to early January and stays under the ice until late March or April. Its main tributary is the Yakhroma River. The town of Klin is located on the Sestra River.