Salisbury is a city in southeastern Maryland, United States. It is the county seat of Wicomico County and the largest city in the state's Eastern Shore region. The population was 30,343 at the 2010 census. Salisbury is the principal city of the Salisbury, Maryland-Delaware Metropolitan Statistical Area. The city is the commercial hub of the Delmarva Peninsula and calls itself "the Crossroads of Delmarva".