Ste. Genevieve (Ste-Geneviève with French spelling) is a city in Ste. Genevieve Township and is the county seat of Ste. Genevieve County, Missouri, United States. The population was 4,410 at the 2010 census. Founded in 1735 by French Canadian colonists and settlers from east of the river, it was the first organized European settlement west of the Mississippi River in present-day Missouri.