Route 66 is an American television drama that premiered on CBS on October 7, 1960, and ran until March 20, 1964, for a total of 116 episodes. The series was created by Herbert B. Leonard and Stirling Silliphant, who were also responsible for the ABC drama Naked City, from which Route 66 was indirectly spun off. Both series employed a format that employed elements of both traditional drama and anthology drama, but there was a difference in where the shows were set: Naked City was set in New York, while Route 66 had its setting change from week to week, with each episode being shot on location in the area in which it was set.