Puy de Dôme (; ) is a large lava dome and one of the youngest volcanoes in the Chaîne des Puys region of Massif Central in south-central France. This chain of volcanoes including numerous cinder cones, lava domes, and maars is far from the edge of any tectonic plate. Puy de Dôme is approximately from Clermont-Ferrand. The Puy-de-Dôme département (with hyphens) is named after the volcano.

Puy-de-Dôme (; lo Puèi de Doma / lo Puèi Domat in the Auvergnat dialect of the Occitan language) is a department in the centre of France named after the famous dormant volcano, the Puy de Dôme.