Puno is a region in southeastern Peru. It is bordered by Bolivia on the east, the Madre de Dios Region on the north, the Cusco and Arequipa regions on the west, the Moquegua Region on the southwest, and the Tacna Region on the south. Its capital is the city of Puno, which is located on Lake Titicaca in the geographical region known as the Altiplano or high sierra.