Potosí or Potosi may refer to:

Bolivia

• Huayna Potosí, a mountain in the LaPaz Department
• Potosí Department, a department of Bolivia
  • Potosí, a city in the Potosí Department
  • Cerro de Potosí, a mountain near the city of Potosí, also known as Cerro Rico; an important Spanish colonial mining site
• Potosí mountain range or Cordillera de Potosí, to the southeast of the city of Potosí
• Wayna Potosí (Oruro), a mountain in the Oruro Department

Potosí is a city and the capital of the department of Potosí in Bolivia. It is one of the highest cities in the world by elevation at a nominal For centuries, it was the location of the Spanish colonial mint.