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PA clan
The
PA clan
(
Proteases
of mixed nucleophile,
superfamily
A
) is the largest group of proteases with common ancestry as identified by
structural homology
. Members have a
chymotrypsin
-like fold and similar
proteolysis
mechanisms but sequence identity of <10%. The clan contains both
cysteine
and
serine proteases
(different
nucleophiles
). PA clan proteases can be found in
plants
,
animals
,
fungi
,
eubacteria
,
archaea
and
viruses
.
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