Mohammad Afzal Khan (1811 – October 7, 1867; ) was the Emir of Afghanistan from 1865 to 1867. The oldest son of Dost Mohammed Khan, Afzal Khan seized power from his brother Sher Ali Khan three years after their father's death. Following Afzal Khan's death the following year, Mohammad Azam Khan was reinstated as Amir of Afghanistan. He was an ethnic Pashtun and belong to the Barakzai tribe.