A supplemental route is a state secondary road in the U.S. state of Missouri, designated with letters. Supplemental routes were various roads within the state which the Missouri Department of Transportation was given in 1952 to maintain in addition to the regular routes, though lettered routes had been in use from at least 1932. The goal of the secondary highway system was to place state-maintained roads within 2 miles (3 km) of more than 95% of all farm houses, schools, churches, cemeteries and stores. The four types of roads designated as Routes are:

• Farm to market roads
• Roads to state parks
• Former alignments of U.S. or state highways
• Short routes connecting state highways from other states to routes in Missouri