Missaukee County is a county located in the U.S. state of Michigan. As of the 2010 census, the population was 14,849. The county seat is Lake City. Originally the county was part of Mackinac County, Michigan, but was split off. Missaukee County was organized in 1871, and is named after a prominent Ottawa chief, Nesaukee, who signed the treaties of 1831 and 1833. However, it is said that "Nesaukee" could be interpreted as 'large mouth of the river.'