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Metachromatic leukodystrophy
Metachromatic leukodystrophy
(
MLD
, also called
Arylsulfatase A deficiency
) is a
lysosomal storage disease
which is commonly listed in the family of
leukodystrophies
as well as among the
sphingolipidoses
as it affects the metabolism of
sphingolipids
. Leukodystrophies affect the growth and/or development of
myelin
, the fatty covering which acts as an insulator around
nerve
fibers throughout the
central
and
peripheral
nervous systems
. MLD involves
cerebroside sulfate
accumulation. Metachromatic leukodystrophy, like most enzyme deficiencies, has an
autosomal recessive
inheritance pattern.
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