Meriwether County is a county located in the U.S. state of Georgia. As of the 2010 census, the population was 21,992. The county seat is Greenville, home of the Meriwether County Courthouse. The county was formed on December 14, 1827 as the 73rd county in Georgia. It was named for David Meriwether, a general in the American Revolutionary War and member of Congress from Georgia.