Maryland Route 272 (MD 272) is a state highway in the U.S. state of Maryland. The state highway runs from Turkey Point within Elk Neck State Park north through North East to the Pennsylvania state line near Calvert, where the highway continues as Pennsylvania Route 272 (PA 272). MD 272 is the main north–south highway of central Cecil County, connecting the Elk Neck between the North East River and Elk River with U.S. Route 40 (US 40) and Interstate 95 (I-95) in North East, MD 273 in Calvert, and Rising Sun via MD 274. The state highway contains a section of MD 274 Truck between MD 274 in Bay View and MD 273 in Calvert.