Major Indoor Soccer League has been the name of three different American professional indoor soccer leagues:

• Major Indoor Soccer League (1978–92), known in its final two seasons as the Major Soccer League
• Major Indoor Soccer League (2001–08), founded by former NPSL teams and later joined by WISL teams
• Major Indoor Soccer League (2008–14), known as the National Indoor Soccer League in 2008 and adopted the MISL name in 2009