Lucius Calpurnius Piso Caesoninus (PW 99) (48 BC – AD 32) was a prominent Roman senator of the early Empire. He was the son of Lucius Calpurnius Piso Caesoninus, consul in 58 BC, and brother of Calpurnia, the third and last wife of Julius Caesar. He was a confidant of the emperors Augustus and Tiberius. His tenure as pontifex led him sometimes to be called Lucius Calpurnius Piso Pontifex, to differentiate him from his contemporary, Lucius Calpurnius Piso the Augur, consul in 1 BC.