Juchitán de Zaragoza (; Spanish name; Isthmus Zapotec: Xabizende ) is an indigenous town in the southeast of the Mexican state of Oaxaca. It is part of the Juchitán District in the west of the Istmo de Tehuantepec region With a 2005 census population of 70,714 inhabitants, it is the fourth-largest city in the state (just barely behind Salina Cruz). The majority of the indigenous inhabitants are Zapotecs and Huaves. The town also serves as the municipal seat for the surrounding municipality, with which it shares a name. The municipality has an area of 414.64 km² (160.1 sq mi) and a population of 85,869, the state's third-largest in population.