The Gladstone Institutes are an independent and nonprofit biomedical research organization whose focus is to better understand, prevent, treat and cure cardiovascular, viral and neurological conditions such as heart failure, HIV/AIDS and Alzheimer's disease. Gladstone researchers study these diseases using techniques of basic and translational science. Another focus at Gladstone is building on the breakthrough development of induced pluripotent stem cell technology by one of its investigators, 2012 Nobel Laureate Shinya Yamanaka, to improve drug discovery, personalized medicine and tissue regeneration.