Interstate 40 (I-40) is a major Interstate Highway running through the south-central portion of the United States generally north of Interstate 10 and Interstate 20 but south of Interstate 70. The western end is at Interstate 15 in Barstow, California; its eastern end is at a concurrency of U.S. Route 117 and North Carolina Highway 132 in Wilmington, North Carolina. Much of the western part of I-40, from Oklahoma City to Barstow, parallels or overlays the historic U.S. Route 66, east of Oklahoma City the route generally parallels U.S. Route 64 and U.S. Route 70. I-40 runs through many major cities including Raleigh, North Carolina; Nashville, Tennessee; Memphis, Tennessee; Little Rock, Arkansas; Oklahoma City, Oklahoma; Amarillo, Texas, and Albuquerque, New Mexico.