Hama ( , Biblical Ḥamāth, "fortress") is a city on the banks of the Orontes River in west-central Syria. It is located north of Damascus and north of Homs. It is the provincial capital of the Hama Governorate. With a population of 854,000 (2009 census), Hama is the fourth-largest city in Syria after Aleppo, Damascus and Homs.

Human anti-mouse antibody (HAMA) is an antibody found in humans which reacts to immunoglobins found in mice.