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HLA-B27
Human leukocyte antigen (HLA) B27
(subtypes B*2701-2759) is a class I surface
antigen
encoded by the B locus in the
major histocompatibility complex
(MHC) on
chromosome 6
and presents antigenic
peptides
(derived from self and non-self antigens) to
T cells
. HLA-B27 is strongly associated with
ankylosing spondylitis
(AS), and other associated inflammatory diseases referred to as "
spondyloarthropathies
". Diseases associated with the HLA-B27 subtype can be remembered with the mnemonic
PAIR
, and include
Psoriasis
,
Ankylosing spondylitis
,
Inflammatory bowel disease
, and
Reiter syndrome
.
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