The Guatiquía River originates on the Chingaza páramo at , from its roots in the jurisdiction of the municipio of Quetame (departament of Cundinamarca, Colombia. Until it reaches the eastern plains or Llanos Orientales Colombianos, it forms a long and deep canyon for . The river splits in two arms taking the names of Río Negrito and Río Guayuriba. Both arms end in the Meta River.