Florence is a city located in Florence County, South Carolina, United States. The city is the county seat of the Florence County and the primary city within the Florence metropolitan area. The area forms the core of the historical "Pee Dee" region of South Carolina, which includes the eight counties of northeastern South Carolina, along with sections of southeastern North Carolina. The U.S. Census Bureau estimated the city's population at 37,326, representing an increase of .7 percent.