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ER-X
ER-X
is a
membrane-associated receptor
that is bound and activated by
17a-estradiol
and
17ß-estradiol
and is a putative
membrane estrogen receptor
(mER). It shows
sequence homology
with
ERa
and
ERß
and activates the
MAPK/ERK pathway
. The receptor is insensitive to the
antiestrogen
ICI-182,780
(fulvestrant).
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