Delaware Route 52 (DE 52) is a state highway in New Castle County, Delaware. The route runs from U.S. Route 13 Business (US 13 Bus.) in downtown Wilmington north to Pennsylvania Route 52 (PA 52) at the Pennsylvania border near Centerville. DE 52 runs through the city of Wilmington and passes through areas of the Brandywine Valley north of Wilmington. DE 52 intersects Interstate 95 (I-95)/US 202 and DE 2 in Wilmington and DE 100/DE 141 and DE 82 in Greenville. The entire route is designated as part of the Brandywine Valley National Scenic Byway, a National Scenic Byway and Delaware Byway while most of the route is also designated as part of the Harriet Tubman Underground Railroad Byway of the Delaware Byways system. The road was built as the Kennett Pike, a turnpike, between 1811 and 1813 at a cost of $30,000. The Kennett Pike was bought by Pierre S. du Pont in 1919 and upgraded to a state highway. The road received the DE 52 designation by 1936.